"Je rêve que l'humanité vive le plus longtemps possible... en bonne santé"
J'aime la vie. Et j'aimerais y goûter le plus longtemps possible. En "bonne santé", physique et mentale. Simple à énoncer, ce désir reste pourtant le plus grand défi de l'humanité. Bien sûr, Faust a toujours hanté la littérature. Mais, en matière de recherche scientifique, il faut reconnaître que la vieillesse et la mort sont presque des sujets tabous. Comme s'il était mauvais d'intervenir sur la nature, l'animal humain ne connaissant que trop son destin inéluctable.
Il y a seulement vingt-cinq ans, la recherche sur la longévité et le vieillissement n'était pratiquement pas à l'ordre du jour. Même le grand Darwin, dont l'oeuvre aborde pratiquement tous les sujets, avait évité ces questions. Quant aux jeunes diplômés en médecine, très peu des meilleurs étudiants s'orientaient jusqu'à présent vers la gériatrie. Moi-même, je ne suis venu que tardivement aux applications anti-âge de la DHEA. Peut-être l'ai-je fait d'ailleurs parce que je vieillis, moi aussi, et que l'atténuation des effets de l'âge est devenue plus urgente.
Mais je suis loin d'être le seul concerné. Songez que la moitié des enfants nés après 2000 deviendront centenaires, et que près de la moitié d'entre eux seront atteints d'une démence irréversible après 85 ans ! Il y a encore un demi-siècle, à 60 ans, on était un vieillard. On mourait relativement jeune et rapidement, d'accidents, d'infections, de maladies cardio-vasculaires. Or il faut se préparer, au XXIe siècle, à mourir plus lentement, beaucoup plus tard, de cancers et de maladies dégénératives atteignant le cerveau. Alors pourquoi ne pas oser le rêve de repousser les effets désastreux du vieillissement ? Je le crois, moi, réalisable.
Oh, je ne cherche pas à passer un pacte d'éternelle jeunesse avec le diable. Ni à créer des Mathusalem. Encore qu'il ne faille rien exclure. Jusqu'à présent, personne n'a dépassé les 122 ans et quelques mois de Jeanne Calment. Mais il n'y a aucune raison pour que ces 122 ans soient une limite absolue. On observe déjà, grâce aux registres d'état civil tenus très rigoureusement dans les pays nordiques, que depuis cent cinquante ans l'âge maximal augmente chaque année, légèrement certes, mais de façon continue. Depuis 1970, il augmente même d'un an tous les dix ans. Il faudrait donc encore quelques siècles pour atteindre les 150 ans, mais ce n'est plus une idée absurde.
En fait, ce n'est pas tant durer qui compte que bien vieillir. Et ce "bien vieillir" ne concerne pas seulement la médecine. Il pèse sur la société tout entière. Sachez que la dépendance a un coût de l'ordre de 3 000 euros par mois en institution et de 10 000 euros chez soi, alors même que la moyenne des retraites est actuellement de 1 000 euros mensuels !
Sachez encore que parvenir à retarder, ne serait-ce que d'un an, la survenue de la dépendance pour 10 % des victimes de la maladie d'Alzheimer représenterait en France 1 milliard d'euros d'économie ! Pour tester chez l'homme nos nouveaux composés neurostéroïdes actifs chez l'animal, mon laboratoire a besoin de 1 million d'euros par an pendant trois ans. Ne croyez-vous pas qu'investir 3 millions pour économiser 1 milliard par an mérite d'être tenté ?
Lorsque j'ai commencé à travailler sur la DHEA, je n'avais pas conscience des développements possibles en matière de prévention des troubles du cerveau. Certes, j'avais découvert, quand j'étais jeune chef de clinique, la sécrétion chez l'homme du sulfate de DHEA, qui diminue avec l'âge, ce qui en fait un marqueur reconnu du vieillissement. Mais, au fond, je n'étais pas très intéressé par le sujet. C'était la grande époque de la biologie moléculaire, et mon intérêt pour la cause des femmes me poussait bien plus à travailler avec cette nouvelle approche sur l'appareil reproductif et le contrôle des naissances. Mon mentor Gregory Pincus, l'inventeur de la pilule contraceptive, avait influencé mon travail de recherche en ce sens. Et j'ai consacré une grande partie de ma carrière de chercheur à l'invention du RU 486, cette pilule abortive qui est utilisée chaque année par des millions de femmes dans le monde entier et qui n'a pas fini de démontrer son utilité dans d'autres indications (accouchements difficiles, contraception d'urgence, fibromes utérins, etc.).
Ce n'est que dans les années 1980 que j'ai repris mes travaux sur la DHEA. Et, comme souvent en matière de recherche, le hasard, les échecs, la prise en considération d'hypothèses peu vraisemblables a priori ont joué un rôle essentiel. C'est ainsi qu'un jour, une de mes techniciennes est entrée dans mon bureau en me disant : "Monsieur, je m'ennuie, donnez-moi quelque chose à faire..." Son directeur de recherche était absent ; alors, pour l'occuper - et parce qu'elle connaissait la DHEA -, je lui ai proposé de reprendre le sujet. "Découpez-moi des rats en tranches, y compris le cerveau, afin que l'on voie s'il y a de la DHEA" (on n'en trouve pas dans le sang chez cet animal). Quelques jours plus tard, elle revenait me voir au comble de l'excitation : "Il y en a, monsieur, il y en a dans le cerveau !" Eh oui ! Dans le cerveau ! Cette hormone n'était donc pas seulement produite par les glandes, mais aussi dans le système nerveux. On découvrait rapidement que les effets de la DHEA sur différents systèmes enzymatiques et récepteurs cérébraux avaient un intérêt certain. Et elle tend non seulement à diminuer l'excès de graisses tissulaires venant avec l'âge, mais elle présente aussi des effets positifs sur la qualité de la peau, les symptômes dépressifs ou même sur les lésions des artères pulmonaires dues à l'insuffisance en oxygène.
Ayant forgé le concept de neurostéroïde, j'avais un instrument original pour étudier les effets du vieillissement, et je l'ai placé depuis au centre de mes travaux. Actuellement, je travaille sur le plus abondant des neurostéroïdes, celui dont la diminution compromet notamment le mécanisme de la mémoire. Or nous avons observé qu'il permet aussi d'augmenter la durée de la vie de petits vers nématodes, appelés C. elegans. Il faudrait donc passer rapidement aux tests sur les mammifères avant de passer à l'homme.
Hélas, la recherche publique ne dispose pratiquement pas de moyens pour ce type de sujet. L'Agence nationale de la recherche, destinée à soutenir des projets innovants, refuse d'inclure dans ses projets un appel d'offres sur le vieillissement. Quant aux laboratoires pharmaceutiques, ils sont peu incités à investir dans ces recherches : il s'agit de produits naturels, donc difficiles à protéger par un brevet, ou alors trop faciles à synthétiser, donc de faible rentabilité. Un peu comme s'il s'agissait de fabriquer d'emblée des médicaments génériques.
C'est l'armée américaine qui a proposé récemment de m'aider ! Dans le cadre des recherches médicales qu'elle finance à l'intention des soldats de la guerre d'Irak, l'US Army observe avec intérêt certains de nos stéroïdes, qui permettent de réparer plus vite et mieux les cellules nerveuses chez l'animal blessé. C'est encourageant, d'autant que, ayant atteint l'âge de la retraite, il m'est désormais interdit d'obtenir des contrats de recherche publique français. J'ai donc créé un site (www.institut-baulieu.org) afin de recueillir des dons, ainsi que la Fondation abritée Vivre longtemps.
Et je ne cesse d'en appeler aux baby-boomeurs, actuellement détenteurs du pouvoir économique, financier et politique. Ils ont cru incarner l'éternelle jeunesse. Pourquoi ne s'inquiètent-ils pas des conditions de leur future vieillesse ? Elle sera longue - tant mieux -, mais ne devraient-ils pas aider à financer une recherche soucieuse d'en éviter les effets déshumanisants ? Pourquoi pas un "lobby des futurs malades" ? Quand on pense qu'il suffirait de quelques millions d'euros pour tester ce que je pense être la genèse d'une pilule de la mémoire ! Oui, il y a des réserves de repotentialisation cérébrale, ce qui veut dire que certains aspects de la dégradation du fonctionnement du cerveau sont réversibles. N'est-ce pas prometteur ?
Si nous obtenions ces financements qui nous manquent tant, alors nos rêves seraient confrontés à la réalité. Retarder, contenir la maladie d'Alzheimer est une première étape urgente, avant de savoir la guérir. A plus court terme, la pilule corrigeant la diminution de la mémoire avec l'âge est une perspective raisonnable. Pour ma part, je "super rêve" que, demain, le plus grand nombre de personnes vieillissantes puissent profiter des fruits de ces recherches. La vie est un tel cadeau !
Fantastique cet extrait dans votre article du "Temps" en Suisse :
"...Et j'ai consacré une grande partie de ma carrière de chercheur à l'invention du RU486, cette pillule
abortive..." et la conclusion "...je superrêve que le plus grand nombre de personnes vieillissantes puissent
profiter des fruits de ces recherches (Nb. cette fois sur la mémoire). La vie est un tel cadeau : " Sic...!!!
Il n'y a pas de petite contradiction.
Pierre-M. Rappaz
Hi there, I dont know if I am writing in a proper board but I have got a problem with activation, link i receive in email is not working... http://www.institut-baulieu.org/?fd2a9ca12b8bbb1533c84831845,
Hi there, I dont know if I am writing in a proper board but I have got a problem with activation, link i receive in email is not working... http://www.institut-baulieu.org/?4b719696a0fce88783b071ec831,
Hi there, I dont know if I am writing in a proper board but I have got a problem with activation, link i receive in email is not working... http://www.institut-baulieu.org/?c0b37eb918f10b574240f9f4637,
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